Na diagnozę neuropsychologiczną często kieruje lekarz, jednak może okazać się ona istotna dla wszystkich osób, które doświadczają chorób neurologicznych (np. choroba Parkinsona, choroba Alzheimera, stwardnienie rozsiane, otępienie z ciałkami Lewy’ego), przebyły udar mózgu lub uraz czaszkowo-mózgowy bądź obserwują u siebie zmiany zachowania lub pogorszenie funkcjonowania poznawczego (np. pamięci, koncentracji uwagi). Wśród niepokojących objawów pacjenci często wymieniają: skłonności do zapominania bieżących zdarzeń, trudności z wydobyciem słowa, tendencje do „gubienia się”, trudności w planowaniu i wykonywaniu bardziej złożonych czynności, wycofanie z relacji. Badanie neuropsychologiczne warto również wykonać w przypadku niektórych zaburzeń psychiatrycznych, w których również mogą występować deficyty poznawcze.
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